Funding

Request for Applications (RFA)

  • Call now open: The South African and UK Medical Research Council’s Request for Applications (RFA) to support Tuberculosis (TB) control implementation science partnerships - Closed
  • SAMRC announces it's first Newton Fund Call with UK MRC and GSK: Non Communicable Diseases - Closed
  • Grand Challenges South Africa: All Children Thriving - Call for Applications - Closed  
  • Drugs and Medical Devices - Award made: 14 February 2014
  • Tuberculosis Vaccine Development HIV Vaccines and Prevention - Award date: April 2014
  • Platinum Group Metal (PGM)-Based Drug Discovery and Medical Device Development. Award date: July 2014

Media Statements

SHIP project awards 2013-2017
as at 12 June 2014

HIV projects
Principal Investigator Institution Project Title
HIV Diagnostics
Ass Prof Jo-Ann Passmore University of Cape Town A GIFT (Genital Inflammation Test) for HIV prevention
Dr Zinhle Makatini University of Limpopo / MEDUNSA To investigate the extent to which drug resistance mutations are missed by standard genotyping methods in various patient populations
HIV Drug Discovery
Prof Marc Weinberg University of the Witwatersrand Novel vector-delivered antiviral therapies for the treatment of latent HIV infection
HIV Vaccines
*Prof Carolyn Williamson University of Cape Town HIV vaccine immunogen design: Identification of T-cell epitopes associated with control of viral replication in Indian and South African HIV-1 infected individuals
*Prof Maria Papathanasopoulos University of the Witwatersrand Comparative immunogenicity of novel Indian and South African HIV-1 subtype C Env peptide and recombinant protein constructs
Prof Penny Moore NICD / University of the Witwatersrand Broad neutralizing HIV antibodies, adjuvants and immunogens
Prof Anna-Lise Williamson University of Cape Town Novel HIV vaccine candidates for South Africa
Prof Maria Papathanasopoulos University of the Witwatersrand Epitope specificities of broadly neutralizing sera from rabbits immunized with HIV-1 Env-2dCD4S60C subunit vaccines
Prof Caroline Tiemessen NICD / University of the Witwatersrand HIV-1 positive South African elite and long term controllers: viral and host targets for HIV functional cure strategies
Prof Carolyn Williamson University of Cape Town Vaccine-mediated effects on immunological, viral and clinical factors in HIV breakthrough infections
Dr Gerald Chege University of Cape Town A novel dual animal pre-clinical platform: Accelerating HIV vaccine product development in South Africa
Dr Jürgen Seier Medical Research Council Maintenance of the Delft rhesus monkey colony
Dr Rachel Chikwamba CSIR Proof of concept study for the production and characterisation of CAP256 monoclonal antibodies in plants
HIV Prevention
Dr Leonard Damelin NICD The selective delivery of broad-spectrum silver-based microbicides and tenofovir using alginate-encapsulation
TB projects
Principal Investigator Institution Project Title
TB Drug Discovery
Dr Digby Warner/Prof Valerie Mizrahi University of Cape Town Smart screening for TB drug discovery
Prof Kelly Chibale University of Cape Town Hit to lead medicinal chemistry optimization of tuberculosis hits
Prof Paul van Helden University of Stellenbosch Profiling of anti-tuberculosis leads in resistant strains of TB
Prof Gerhard Walzl University of Stellenbosch South African Tuberculosis Bioinformatics Initiative (SATBBI) - in support of systems biology approaches to tuberculosis biomarker research
Dr Bavesh Kana/Dr Bhavna Gordhan University of the Witwatersrand TB activity (MIC99) profiling
Prof Anneke Hesseling University of Stellenbosch TB child and adolescent multi-drug resistant preventive therapy trial (TB CHAMP) - phase III trial
Dr Adrie Steyn KwaZulu-Natal Research Institute for TB-HIV (K-RITH) Pharmacological targeting of Mycobacterium tuberculosis bioenergetic pathways
TB Diagnostics
Prof Keertan Dheda University of Cape Town A non-sputum-orientated ultra-sensitive point of care diagnostic device for TB using a lateral flow assay coupled to an electrochemical readout (TB-PROTEC)
Prof Jonathan Blackburn University of Cape Town A hand-held, low cost aptamer-based Surface Enhanced Raman Scattering biosensor for multiplexed pathogen detection – towards the ‘tricorder'
Prof Jonathan Blackburn University of Cape Town Translating novel urinary TB biomarkers into a point of care test for diagnosing tuberculosis disease in low resource settings
Prof Anne Grobler North West University Rapid diagnosis of tuberculosis in resource-poor settings
TB Vaccines
Prof Keertan Dheda University of Cape Town A human lung-orientated approach to correlates of risk in tuberculosis - The TB-HART study
Dr Thomas Scriba University of Cape Town Systems immunology of ID93 vaccine-induced protection against recurrent TB disease
Hon Prof Robert Wilkinson University of Cape Town Blood signature of recent tuberculosis infection or re-infection
Dr Pholo Maenetje The Aurum Institute Defining the functional αβ and γ9δ2 T cell responses associated with protective TB immunity
Non Communicable Diseases projects
Principal Investigator Institution Project Title
NCD Drug Discovery           
Dr Johan Louw Medical Research Council Profiling of Asphalatin
NCD Diagnostics
Dr Johan Louw Medical Research Council Early diabetes diagnostic
Dr Junaid Gamieldien University of the Western Cape Development of a clinical exome sequencing solution and its application to diabetes mellitus and related disorders
Prof Maritha Kotze University of Stellenbosch Development of a clinically applicable diagnostic test kit and pharmacogenomics algorithm for breast cancer
Medical Devices
Dr Mohammed Khan Dalwai The Open Medicine Project South Africa Mobile Triage Solution
Malaria projects
Principal Investigator Institution Project Title
Malaria Drug Discovery
Prof Kelly Chibale University of Cape Town SAMI hit to lead and lead optimization anti-malarial programme
Dr Dalu Mancama CSIR Biosciences South African malaria transmission blocking group - the identification, validation and characterisation of chemical entities with potential malaria transmission blocking ability
Prof Lyn-Marie Birkholtz University of Pretoria South African malaria transmission blocking group - the identification, validation and characterisation of chemical entities with potential malaria transmission blocking ability
Prof Theresa Coetzer NHLS / University of the Witwatersrand South African malaria transmission blocking group - the identification, validation and characterisation of chemical entities with potential malaria transmission blocking ability
Prof Lizette Koekemoer University of the Witwatersrand Mosquito-parasite Infection Resource Centre (MIRC)

*Projects from the previous SHARP initiative

Contact Details
2nd Floor Building A, MRC Medicina Campus, Francie van Zijl Drive, Parow Valley, Cape Town
Tel: 021 938 0351; Fax: 021 938 0385; Email: info.ship@mrc.ac.za


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